Kunnen blebs weer veranderen in spirocheten?

[Sproetje]

Blebs zitten ook in de darmen van de teek:

[Sproetje]

Per toeval kwam ik iets tegen uit de bieb van lymerick.net
Het is een onderzoek van Brorson en noemt ook dat blebs in filamenten kunnen veranderen,

A rapid method for generating cystic forms of Borrelia burgdorferi, and their reversal to mobile spirochetes.

Brorson O; Brorson SH. 1998
APMIS, 106(12):1131-41

Motile B. burgdorferi spirochetes converted to cysts within 1 minute when placed in distilled water. The cysts reverted back to spirochetes after transfer to a growth medium. "Dark field microscopy demonstrated that >95% of the normal mobile borreliae were converted to cystic forms after 1 min exposure to distilled water. It seemed as if the cysts were produced by the bacterium whirling into its own membrane-encapsulated space. ...Four hours after inoculation no normal spirochetes were observed in the distilled water, and all cysts were globularly shaped. ...The conversion to cystic forms occurred more rapidly if the temperature of the distilled water added was 4ºC than if it was 22ºC. ... Cysts transferred to the BSK-H medium became irregular and their volume shrank, possibly due to different osmolarity in the BSK-H medium than in distilled water. Daily observations of the cysts in BSK-H medium revealed one to five thin filamentous structures fastened to the envelope of the cysts. In the beginning, these structures were hypermobile and their shape was rectilinear or slightly curved (Fig. 2a). Subsequently, these filamentous forms grew both in length and diameter, and many of them acquired the shape of normal spirochetes that finally detached from the cysts. ... The biological activity of the cystic forms was confirmed by the step by step development to normal mobile spirochetes in BSK-H medium, and also indicated by the presence or RNA in 5-week-old cysts due to red-orange staining with acridine orange (pH 6.4) (Fig. 4b). ... The observation by TEM that blebs transformed into thin filaments leads us to speculate that these filaments develop to normal mobile spirochetes. If so, the blebs have to contain enough genetic material to synthesize a new bacterium (22). ...Similar cystic forms may occur in the human organism (11, 14, 15), and they may explain the long periods or latency, resistance to antibiotics, negative serological results (3-7, 10, 12, 13, 25), and low PCR sensitivity (5,8,10)."

[VerlorengezondheidM]

ik vroeg me tegelijkertijd ook af of die blebs na verloop van tijd misschien weer nieuwe spirocheten kunnen worden?

The Complexities of Lyme Disease (A Microbiology Tutorial) by Thomas M. Grier

Another unique feature to Borrelia burgdorferi are Blebs.

This bacteria replicates specific genes, and inserts them into its own cell wall, and then pinches off that part of its cell membrane, and sends the Bleb into the host. Why it does this we don’t know? But we do know that these blebs can irritate our immune system. Dr. Claude Garon of Rocky Mountain Laboratories has shown that there is a precise mechanism that regulates the ratio of the different types of blebs that are shed. (46) In other bacteria the appearance of blebs often means the bacteria can share genetic information between themselves. We don’t know if this is possible with Borrelia species. There have been reports of a granular form of Borrelia, which can grow to full size, fully autonomous spirochetes and can reproduce. These granules are so small that they can be filtered and separated from live adult spirochetes by means of a micro-pore filter. The granular/spore form of Borrelia burgdorferi is still being debated. (Stealth Pathogens Lida Mattman Ph.D 66, Phillips/Mattman 98, Preac-Mursic)

the_complexities_of_lyme_disease.pdf

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