Henriëtte schreef:Besmetting vindt ook plaats van mens op mens via aërogene druppels en/of handen.
Kan bij ouderen en/of immuno-incompetenten ernstig tot levensbedreigend zijn.
Persisterende infecties komen vaak voor.
https://lci.rivm.nl/richtlijnen/chlamydia-pneumoniae
Henriëtte
Laboratory diagnosis of persistent human chlamydial infection
The clinical spectrum of human chlamydial infections includes clinically unapparent infections, acute symptomatic infections as well as persistent infections (defined as the presence of viable but non-cultivable chlamydiae). Persistent Chlamydia psittaci infection in cultured cells was described over 30 years ago (Moulder et al., 1980). Similar continuous infection models in cell lines without external induction have later been established for Chlamydia trachomatis (Lee and Moulder, 1981) and Chlamydia pneumoniae (Kutlin et al., 1999). In cultured cells, persistent infection can also be induced by external factors, including amino acid starvation, interferon-γ-induced tryptophan deprivation, iron chelation, tobacco smoke and viral co-infection as well as by exposure to antimicrobial agents (for review, see Beatty et al., 1994; Hogan et al., 2003). Furthermore, chlamydial infection in monocyte/macrophage cultures has the appearance of a persistent infection (Mannonen et al., 2004, 2011). The presence of large, pleomorphic reticulate bodies, named aberrant bodies, inhibition of binary fission and inability of the aberrant bodies to transform into infectious elementary bodies, characterize in vitro persistence. Transcriptomic and proteomic analyses have confirmed that there is continued genome replication and messenger RNA synthesis in the aberrant bodies, but altered cell division (Nicholson et al., 2003; Mäurer et al., 2007).
Bron: NCBI lees meer
