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Brain Inflammation A Hallmark Of Autism, Large-Scale Analysis Shows
Johns Hopkins study is largest so far of gene expression in autism brains
Release Date: December 10, 2014

While many different combinations of genetic traits can cause autism, brains affected by autism share a pattern of ramped-up immune responses, an analysis of data from autopsied human brains reveals.

“There are many different ways of getting autism, but we found that they all have the same downstream effect,” says Dan Arking, Ph.D., an associate professor in the McKusick-Nathans Institute for Genetic Medicine at the Johns Hopkins University School of Medicine. “What we don’t know is whether this immune response is making things better in the short term and worse in the long term.”

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism
Simone Gupta, Shannon E. Ellis, Foram N. Ashar, Anna Moes, Joel S. Bader, Jianan Zhan, Andrew B. West & Dan E. Arking
Nature Communications 5, Article number: 5748 doi:10.1038/ncomms6748
Published 10 December 2014

Recent studies of genomic variation associated with autism have suggested the existence of extreme heterogeneity. Large-scale transcriptomics should complement these results to identify core molecular pathways underlying autism. Here we report results from a large-scale RNA sequencing effort, utilizing region-matched autism and control brains to identify neuronal and microglial genes robustly dysregulated in autism cortical brain. Remarkably, we note that a gene expression module corresponding to M2-activation states in microglia is negatively correlated with a differentially expressed neuronal module, implicating dysregulated microglial responses in concert with altered neuronal activity-dependent genes in autism brains. These observations provide pathways and candidate genes that highlight the interplay between innate immunity and neuronal activity in the aetiology of autism.

Paardentherapie voor autistische kinderen in Nederland"

It is estimated that up to 90% of children with autism may be also infected with Lyme Disease/Borrelia however, since testing is difficult, current research shows that 20-30% of these children harbor this bacteria.

Chronic co-infections in autism spectrum disorders

hope schreef:Heeft het zin om mijn zoon met autisme te laten testen op lyme

hope schreef: als ik zelf niet beter wordt na 10 maanden ab en blijf achteruitgaan???