2019 Hopkins Study
Recommended Tests Miss
72.2% Those Infected With Lyme Disease
Studies over the past 15 years continue to show approximately 3/4 of those tested for Lyme disease using the IDSA/CDC recommended tests (75%, 74.9% and 72.2%)...
Were false negative!
Lucy Barnes
Regarding the Vaccine & Therapeutics Subcommittee
Putting The Cart in Front of the Horse Are We?
In 2005, Johns Hopkins published a study indicating lab tests for Lyme disease missed approximately 75% of the people who were infected. (1)
Over a decade later, a study by Michael Cook, et. al. determined 74.9% of those infected had false-negative Lyme test results. (2)
Obviously, Lyme tests are NOT any more accurate today than in the past.
In fact, many medical professionals on the front lines treating the growing number of chronically ill patients believe the percentages of missed Lyme cases are much higher- up to 90%.
When conclusions in scientific studies are based on results of inaccurate Lyme tests, the study's conclusions will be flawed. When the same flawed studies and same flawed tests are used in the development of a Lyme vaccine, the vaccine can't help but be seriously flawed.
Stakeholders who have vehemently pushed to keep the failed Lyme tests on the market to the exclusion of others (3) are also involved with and are dependent on the success of the vaccine. (4)
This new (recycled) Lyme vaccine currently in clinical trials is projected by Valneva to be worth approximately $900,000,000 (U.S. dollars) annually.(5) Its review and subsequent approval is being determined by the same stakeholders who continue to promote and profit from the failed Lyme tests.
Although the promise of nearly one billion dollars a year is inviting, there should be no Lyme vaccines approved, mandated or distributed until there are accurate Lyme tests on the market.
It’s that simple.
Lucy Barnes
Maryland
ELISA Antibody Testing
1. Over 75% of patients with chronic Lyme are negative by ELISA
Western Blot
1. Reflects antibody response to specific Bb antigens
2. Different sensitivities and specificities of the bands
3. Some bands are potentially seen in different bacteria – “nonspecific bands”
4. Some bands are specific to spirochetes
5. Some bands are specific to Bb
6. Specific: 18, 23-25, 28, 31, 34, 37, 39, 58, 83 & 93
7. Spirochetes in general: 41 (flagellum)
8. First immune response if present is usually 41 and 23 KD bands
9. Response to the 31 KD proteins is not usually seen for a year after initial infection
CDC IGG Western Blot Criteria
1. IGG Western Blot 5 of the 10 bands (18,23,28,30,39,41,45,58,66)
2. Criteria based on early Lyme
3. IGENEX adds 3 specific bands (31,83 and 34) and 3 non-specific bands (22,37,73)
CDC IGM Western Blot Criteria
1. IGM WB 2 of the 3 bands 23, 39, 41
2. IGENEX adds 3 specific bands (31,34 and 83) and 3 non-specific bands (22,37,73)
Revised Criteria with Western Blot
1. IGG WB: 2 specific band criteria has demonstrated improved sensitivity and maintained specificity
2. Can diagnose Lyme if any one band (IgG or IgM) of 18, 23, 28, 39 or 58 kDa or if any 2 or more of the following bands are present; 30, 45,41 and 93
3. If negative or require further confirmation, can obtain IGENEX WB (adds specific bands of 31, 34 an 83, which are typically seen in chronic disease)
4. Positive if any one band of 18, 23, 28,31,34, 39, 58 or 83
Enz.. lees meer
https://www.prohealth.com/library/dr-ho ... ture-28551
Henriëtte
On testing 26 CSF samples from patients with clinical
and serological diagnosis of active neuroborreliosis
(intrathecally produced borrelial specific antibodies, elevated cell count in CSF or
damage of blood-brain barrier) we could not detect any of the three
antigens nor did we obtain a positive result with the whole-cell extract ELISA.
This disappointing result may be explained by
the possibility that the amount of free detectable antigen in CSF
is lower than the detection limits of the inhibition ELISA tests
in this study for the following reasons:
(1) spirocheates may adhere at the meninges or at neuronal tissue: or
(2) antigens might be bound in immune complexes.
..........
We conclude that the detection of borrelial components in CSF by competitive inhibiton ELISA is not a useful approach in the laboratory diagnosis of neuroborreliosis in respect of the antigens tested in this study.
NEW STUDY SHOWS LESS THAN ONE-THIRD OF LYME DISEASE TEST RESULTS ARE ACCURATE FOR PATIENTS WITH LYME RASH
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