Door: Kay Lazar
https://www.bostonglobe.com/metro/2015/ ... story.html
Post-treatment Lyme disease patients often have problems with memory and thinking, similar to patients who have suffered concussions or other brain injuries, said Dr. Nevena Zubcevik, a brain injury researcher and co-director of the new center. The patients may struggle with work, remembering appointments, or figuring out how to pay bills.
“We are trying to respond in the face of an epidemic, and this is a population in dire need,” Zubcevik said.
Health insurance companies have covered most services at Spaulding for the first batch of post-treatment Lyme patients, the doctors said. But there is one service that will be offered free of charge — mental health counseling. That was the wish of Brandi and Chris Dean, whose donation allowed Spaulding to launch the center bearing their name.
Brandi Dean, a 38-year-old Wellesley mother, was diagnosed with Lyme in 2011. But Dean said she was treated horribly by many doctors who dismissed her vertigo, confusion, strange weakness, and heart palpitations as anxiety because she had just given birth to her second son.
“I have seen patients so critically ill, they can’t get up,” Fallon said.
One patient, a 14-year-old boy, was so debilitated he was in a wheelchair and needed dark glasses and headphones to buffer the severe sensitivity he developed to light and noise.
“He spent a number of months at a rehab facility for children and got tremendous help from that,” Fallon said.
De reden dat lyme symptomen kunnen resideren kan ook een oorzaak vinden in het post sepsis:
It has been suggested that Lyme is immunosuppressive causing a post-sepsis like immunosuppression: (AIDS-like disease)
Dormant viruses re-emerge in patients with lingering sepsis, signaling immune suppression
June 11, 2014
http://news.wustl.edu/news/Pages/27015.aspx
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.
http://www.ncbi.nlm.nih.gov/m/pubmed/24 ... iss+sepsis
NEW, by the NIH: "Surviving Sepsis: Detection and Treatment Advances"
By Carolyn Beans for the National Institutes of Health | August 18, 2014 08:43am ET
http://www.livescience.com/47387-sepsis ... nigms.html
Preventing Secondary Infections
"Some people who survive sepsis can develop secondary infections days or even months later. A research team that included Richard Hotchkiss, Jonathan Green and Gregory Storch of Washington University School of Medicine in St. Louis suspected that this is because sepsis might cause lasting damage to the immune system. To test this hypothesis, the scientists compared viral activation in people with sepsis, other critically ill people and healthy individuals. The researchers looked for viruses like Epstein-Barr and herpes simplex that are often dormant in healthy people but can reactivate in those with suppressed immune systems. [Sepsis Has Long-Term Impact for Older Adults, Study Finds]"
Lyme disease subverts immune system, prevents future protection
July 2, 2015
http://news.ucdavis.edu/search/news_det ... o?id=11254
“The bacteria that cause Lyme disease are able to trick an animal’s immune system into not launching a full-blown immune response or developing lasting immunity to the disease, report researchers at the University of California, Davis.”
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Per the following study, reactivated Epstein Barr was cleared after anti-malarial treatment:
PLoS One. 2011;6(10):e26266. doi: 10.1371/journal.pone.0026266. Epub 2011 Oct 24.
Effect of acute Plasmodium falciparum malaria on reactivation and shedding of the eight human herpes viruses.
Chêne A1, Nylén S, Donati D, Bejarano MT, Kironde F, Wahlgren M, Falk KI.
Author information
1Department of Microbiology Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm,
Abstract
Human herpes viruses (HHVs) are widely distributed pathogens. In immuno-competent individuals their clinical outcomes are generally benign but in immuno-compromised hosts, primary infection or extensive viral reactivation can lead to critical diseases. Plasmodium falciparum malaria profoundly affects the host immune system. In this retrospective study, we evaluated the direct effect of acute P. falciparum infection on reactivation and shedding of all known human herpes viruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6, HHV-7, HHV-8). We monitored their presence by real time PCR in plasma and saliva of Ugandan children with malaria at the day of admission to the hospital (day-0) and 14 days later (after treatment), or in children with mild infections unrelated to malaria. For each child screened in this study, at least one type of HHV was detected in the saliva. HHV-7 and HHV-6 were detected in more than 70% of the samples and CMV in approximately half. HSV-1, HSV-2, VZV and HHV-8 were detected at lower frequency. During salivary shedding the highest mean viral load was observed for HSV-1 followed by EBV, HHV-7, HHV-6, CMV and HHV-8. After anti-malarial treatment the salivary HSV-1 levels were profoundly diminished or totally cleared.
So what is my point to all this you might ask?
It is quite possible that reactivated viruses found in Post-Treatment Lyme Disease Syndrome are actually an indirect marker for persistent Borrelia infection.
PS.
Sorry dat het er in het engels staat, ben vandaag niet in staat om te vertalen.