Lyme bacterie overleeft 28 dagen doxycycline nog maanden daarna

[Sproetje]

Living B burgdorferi spirochetes were found in ticks that fed upon primates and in multiple organs after treatement with 28 days of doxycycline.

Uit: Science News
December 2017

https://www.sciencedaily.com/releases/2 ... 143613.htm

Based on a single, extensive study of Lyme disease designed by Tulane University researchers, the study employed multiple methods to evaluate the presence of Borrelia burgdorferi spirochetes, the bacteria that cause Lyme disease, before and after antibiotic treatment in primates. The study also measured the antibody immune response to the bacteria both pre- and post- treatment, as this is how current diagnostics typically evaluate Lyme disease in humans.

Journal References:
Monica E. Embers, Nicole R. Hasenkampf, Mary B. Jacobs, Amanda C. Tardo, Lara A. Doyle-Meyers, Mario T. Philipp, Emir Hodzic. Variable manifestations, diverse seroreactivity and post-treatment persistence in non-human primates exposed to Borrelia burgdorferi by tick feeding.
PLOS ONE, 2017; 12 (12): e0189071 DOI: 10.1371/journal.pone.0189071

Nicholas A. Crossland, Xavier Alvarez, Monica E. Embers.
Late Disseminated Lyme Disease: Associated Pathology and Spirochete Persistence Post-Treatment in Rhesus Macaques.
The American Journal of Pathology, 2017; DOI: 10.1016/j.ajpath.2017.11.005

[Henriëtte]

Study finds Lyme bacteria can survive antibiotic treatment month after infection;

“It is apparent from these data that B. burgdorferi bacteria, which have had time to adapt to their host, have the ability to escape immune recognition, tolerate the antibiotic doxycycline and invade vital organs such as the brain and heart,” said lead author Monica Embers, assistant professor of microbiology and immunology at Tulane University School of Medicine. “Although current antibiotic regimens may cure most patients who are treated early, if the infection is allowed to progress, the 28-day treatment can be insufficient, based on these findings.”

The study also found:

All subjects treated with antibiotics were found to have some level of infection 7 – 12 months post treatment.
Despite testing negative by antibody tests for Lyme disease, two of 10 subjects were still infected with Lyme bacteria in heart and bladder.
Lyme bacteria which persist after antibiotic treatment are still viable.

https://news.tulane.edu/pr/study-finds- ... -infection

Henriëtte

[Sproetje]

Lacto Bacto schrijft er ook over:

https://lactobacto.com/2017/12/14/some- ... treatment/

[....]
However, many medical professionals deny that a person can still have Lyme disease after antibiotic treatment, and instead call the lingering symptoms post-treatment Lyme disease syndrome (PTLDS).
[....]
Hah! The Tulane University researchers found that yes, the live bacteria (B. burgdorferi spirochetes) can still be there in different organs of the body even after 28 days of antibiotic treatment. They studied late Lyme disease in both treated (with antibiotics) and untreated rhesus macaques - primates in which Lyme disease has effects similar to humans. Other studies have also found that the Lyme disease bacteria can evade treatment
[....]

[Sproetje]

Interessant vind ik ook dat er negatief getest werd na de kuur met doxycycline met antistoffen test, maar nog wel spirocheten aanwezig waren.
En vooral ook dat er bij de aap die een klassieke EM vertoonde, helemaal geen antistoffen waren te zien, voor alle 5 antigenen, gedurende de hele studie periode, niet vóór de behandeling, niet tijdens, en niet na de behandeling met doxy

https://medicalxpress.com/news/2017-12- ... otics.html

The results show:

* Few subjects displayed a rash. Although all subjects were infected, only one of the 10 displayed a rash with central clearing, the classical "bulls-eye" rash. The subject that developed this rash, interestingly, never mounted an immune response to five borrelia antigens throughout the study period, prior to and following treatment.

* Organs may be infected even if antibody tests are negative. One subject which tested negative for B. burgdorferi by skin biopsy cultures, PCR and in vivo cultures, was found to have B. burgdorferi infecting the heart. Another untreated subject, who was ultimately shown to have residual Lyme bacteria inthe bladder, showed a decrease in immune response over the course of infection, with a negative xenodiagnosis test in the late stage, which would signal that the animal self-cured.

* Intact spirochetes were found in three of five treated and four of five untreated subjects based on xenodiagnosis results 12 months after the tick bite.

* Immune responses to B. burgdorferi varied greatly post-treatment, with one subject's antibody levels dropping to pre-bite levels for three antigens while another subject experienced elevated antibodies for the same antigens throughout the study period. This is significant because it demonstrates that subjects infected with the same strain of B. burgdorferi may have different immune responses to the same antigen. And, because humans, like primates, are genetically diverse, it underscores that testing antibody responses may be inherently unreliable as a singular diagnostic modality for Lyme disease.

* Widespread and variable microscopic disease was observed in all infected subjects, despite antibiotic treatment. Compared to uninfected subjects of the same age, infected subjects in this study (treated and untreated) demonstrated Inflammation in and around the heart, in skeletal muscles, joints, and the protective sheath that covers the brain, and near peripheral nerves.

* Rare, but intact B. burgdorferi spirochetes were found in the tissues of both the treated and untreated subjects. In two subjects treated with doxycycline, multiple Lyme bacteria were observed in the brain tissue. Others organs in which the spirochetes were observed included the heart, joints, bladder, skeletal muscle and adjacent to peripheral nerves.

[Sproetje]

Belangrijk nog te zeggen is dat de doxy pas werd gegeven 4 maanden nadat een aantal resusaapjes werden geïnfecteerd.

https://www.lymeneteurope.org/forum/vie ... f=5&t=6285

[Henriëtte]

New Study finds Lyme bacteria survive a 28-day course of antibiotics when treated 4 months after infection by tick bite;

All subjects treated with antibiotics were found to have some level of infection 7–12 months post treatment.Despite testing negative by antibody tests for Lyme disease, two of 10 subjects were still infected with Lyme bacteria in heart and bladder. Lyme bacteria which persist are still viable.

[quote]The data show that living B. burgdorferi spirochetes were found in ticks that fed upon the primates and in multiple organs after treatment with 28 days of oral doxycycline. The results also indicated that the immune response to the bacteria varied widely in both treated and untreated subjects.
It is apparent from these data that B. burgdorferi bacteria, which have had time to adapt to their host, have the ability to escape immune recognition, tolerate the antibiotic doxycycline and invade vital organs such as the brain and heart[/quote]

https://www.bayarealyme.org/blog/new-st ... tick-bite/

Henriëtte

[Henriëtte]

Tulane University 13 December 2017; New Study finds Lyme bacteria survive a 28-daycourse of antibiotics when treated four month after infection by a tick bite;

The data show that living B. burgdorferi spirochetes were found in ticks that fed upon the primates and in multiple organs after treatment with 28 days of oral doxycycline. The results also indicated that the immune response to the bacteria varied widely in both treated and untreated subjects.
“It is apparent from these data that B. burgdorferi bacteria, which have had time to adapt to their host, have the ability to escape immune recognition,tolerate the antibiotic doxycycline and invade vital organs such as the brain and heart,” said lead author Monica Embers, PhD, assistant professor of microbiology and immunology at Tulane University School of Medicine.
“In this study, we were able to observe the existence of microscopic disease and low numbers of bacteria, which would be difficult to ‘see’ in humans but could possibly be the cause of the variable and nonspecific symptoms that are characteristic of post-treatment Lyme disease syndrome. Although current antibiotic regimens may cure most patients who are treated early, if the infection is allowed to progress, the 28-day treatment may be insufficient, based on these findings,” Embers said.

http://www.newswise.com/articles/view/6 ... y=10020971

Henriëtte