Suicide and Lyme and associated diseases

[Josie]

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481283/

Suicide and Lyme and associated diseases
Robert C Bransfield
Neuropsychiatr Dis Treat. 2017; 13: 1575–1587. Published online 2017 Jun 16. doi: 10.2147/NDT.S136137 PMCID: PMC5481283

Abstract
Purpose
The aim of this paper is to investigate the association between suicide and Lyme and associated diseases (LAD). No journal article has previously performed a comprehensive assessment of this subject.

Introduction
Multiple case reports and other references demonstrate a causal association between suicidal risk and LAD. Suicide risk is greater in outdoor workers and veterans, both with greater LAD exposure. Multiple studies demonstrate many infections and the associated proinflammatory cytokines, inflammatory-mediated metabolic changes, and quinolinic acid and glutamate changes alter neural circuits which increase suicidality. A similar pathophysiology occurs in LAD.

Method
A retrospective chart review and epidemiological calculations were performed.

Results
LAD contributed to suicidality, and sometimes homicidality, in individuals who were not suicidal before infection. A higher level of risk to self and others is associated with multiple symptoms developing after acquiring LAD, in particular, explosive anger, intrusive images, sudden mood swings, paranoia, dissociative episodes, hallucinations, disinhibition, panic disorder, rapid cycling bipolar, depersonalization, social anxiety disorder, substance abuse, hypervigilance, generalized anxiety disorder, genital–urinary symptoms, chronic pain, anhedonia, depression, low frustration tolerance, and posttraumatic stress disorder. Negative attitudes about LAD from family, friends, doctors, and the health care system may also contribute to suicide risk. By indirect calculations, it is estimated there are possibly over 1,200 LAD suicides in the US per year.

Conclusion
Suicidality seen in LAD contributes to causing a significant number of previously unexplained suicides and is associated with immune-mediated and metabolic changes resulting in psychiatric and other symptoms which are possibly intensified by negative attitudes about LAD from others. Some LAD suicides are associated with being overwhelmed by multiple debilitating symptoms, and others are impulsive, bizarre, and unpredictable. Greater understanding and a direct method of acquiring LAD suicide statistics is needed. It is suggested that medical examiners, the Centers for Disease Control and Prevention, and other epidemiological organizations proactively evaluate the association between LAD and suicide.

Robert Bransfield, oud president van ILADS, licht deze emotioneel beladen studie persoonlijk toe in een korte videopresentatie, ook te vinden in de link.

De ziekte van Lyme heeft heel veel verschillende uitingsvormen, hierbij kunnen ook (neuro-)psychiatrische symptomen voorkomen. Er zijn mensen (waaronder ook artsen), ook al zijn ze dun gezaaid, die kennis, begrip en empathie hebben en tot steun en hulp kunnen zijn...


Informatie van de lymevereniging bij veelgestelde vragen:
https://lymevereniging.nl/lyme/veelgest ... e60dc-89c7

- Ik ben behandeld met antibiotica en heb nog steeds klachten, wat nu?


Zolang er klachten zijn, kan er sprake zijn van een actieve infectie. Vraag uw (huis)arts om een verlenging / voortzetting van de behandeling als er mogelijk sprake is van een voortdurende infectie.

Zorg dat u goed op de hoogte bent van de problematiek die er is op het gebied van de diagnose en behandeling van Lyme-Borreliose, zodat u met uw arts hierover in gesprek kan gaan.

Wijs uw arts op het bestaan van meerdere richtlijnen voor de behandeling van Lyme en geef aan volgens welke richtlijn u behandeld wilt worden. Zoek een andere arts wanneer uw arts niet tot behandeling over wil gaan en u wel een langere behandeling wilt uitproberen.

Josie

[VerlorengezondheidM]

@Josie,

Bedankt voor het delen!

De korte video maakt alles nog duidelijker, een echte eyeopener

Opvallend: die strikte Lyme criteria gelden helemaal niet als het om deze ernstige, levensbedreigende Lyme klachten gaat

[Josie]

Graag gedaan!

Een gepubliceerde reactie op de bovenstaande studie:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546819/

Neuropsychiatr Dis Treat. 2017 Aug 2;13:2069-2071. doi: 10.2147/NDT.S145359. eCollection 2017.
Suicidal and homicidal tendencies after Lyme disease: an ignored problem.
Munir A1, Aadil M2, Rehan Khan A3.

Dr Bransfield inferred the possible prevalence of suicide associated with LAD by an indirect method which revealed that 414,540 patients with LAD have suicidal ideation, 31,100 attempt suicide and a total of 1,244 commit suicide in the USA per year from LAD.1,2
(…)
A case report published in 2013 by Banerjee et al is an example where a case of 44-year-old male without any past psychiatric history presented with a third unsuccessful suicide attempt and was later diagnosed as having Borrelia infection. After 1 month of medical therapy with intravenous ceftriaxone, resulted in improvements in his mental status and resolution of suicidal ideation.3
(…)
Another set of cases was reported earlier in the 1990s by Fallon et al, highlighting suicidality in patients with Lyme disease. One of the two patients presented with neurological symptoms including fatigue, frontal headaches, and memory loss, and the second with a flu-like illness, joint pain, swollen glands, and fever. After further investigations, both of these patients were diagnosed with Lyme disease and appropriate treatment was offered. Few months after the treatment, both patients developed severe depression along with suicidal threats and an attempt by one patient. An evidence of persistent Lyme borreliosis was found in both cases.4

Uit de reactie van dr. Bransfield:

The article by Fallon et al that you quoted describes two patients with LAD who were both suicidal and aggressive.1 I treated both of these patients, and in addition, I have been able to follow the status of Patient B over a span of 30 years. This patient was highly suicidal, had horrific intrusive images of killing others, and had violent impulses which were eliminated with treatment. Patient A was also suicidal, violent, and physically assaultive to her son. In both patients, combined antibiotic and psychotropic treatment helped them recover and was clearly life saving.

Josie

[Sproetje]

Eentje uit 1994:

Lyme disease: a neuropsychiatric illness
Published online: April 01, 2006

http://ajp.psychiatryonline.org/doi/abs ... 51.11.1571

Abstract
OBJECTIVE: Lyme disease is a multisystemic illness that can affect the central nervous system (CNS), causing neurologic and psychiatric symptoms. The goal of this article is to familiarize psychiatrists with this spirochetal illness. METHOD: Relevant books, articles, and abstracts from academic conferences were perused, and additional articles were located through computerized searches and reference sections from published articles. RESULTS: Up to 40% of patients with Lyme disease develop neurologic involvement of either the peripheral or central nervous system. Dissemination to the CNS can occur within the first few weeks after skin infection. Like syphilis, Lyme disease may have a latency period of months to years before symptoms of late infection emerge. Early signs include meningitis, encephalitis, cranial neuritis, and radiculoneuropathies. Later, encephalomyelitis and encephalopathy may occur. A broad range of psychiatric reactions have been associated with Lyme disease including paranoia, dementia, schizophrenia, bipolar disorder, panic attacks, major depression, anorexia nervosa, and obsessive-compulsive disorder. Depressive states among patients with late Lyme disease are fairly common, ranging across studies from 26% to 66%. The microbiology of Borrelia burgdorferi sheds light on why Lyme disease can be relapsing and remitting and why it can be refractory to normal immune surveillance and standard antibiotic regimens. CONCLUSIONS: Psychiatrists who work in endemic areas need to include Lyme disease in the differential diagnosis of any atypical psychiatric disorder. Further research is needed to identify better laboratory tests and to determine the appropriate manner (intravenous or oral) and length (weeks or months) of treatment among patients with neuropsychiatric involvement

[Henriëtte]

Lyme psychose en andere neurologische symptomen:

https://www.ntvg.nl/artikelen/lyme-psychose/volledig

Henriëtte

[Sproetje]

Het hoort dus al bekent te zijn onder de huisartsen dat dit soort uitingen bij borreliose kunnen horen.
Het Nederlands Tijdschrift voor Geneeskunde noemt het al in 1993, dat wist ik niet dat het al zoooo lang bekend is onder de Nederlandse artsen.

Maar als er altijd alleen maar afgegaan wordt op te testen van het liquor, dan worden er veel mensen met deze klachten weer naar huis gestuurd, ik denk dan met alle gevolgen van dien.
Wat is er eigenlijk veranderd sindsdien?

Dr. Willy Burgdorfer zei het zelfs al in 1991:

https://link.springer.com/article/10.10 ... 63?LI=true

Encephalomyelitis
Among the more recently recognized manifestations of Lyme borreliosis is Borrelia encephalomyelitis or tertiary borreliosis
a syndrome that differs from the common and spontaneously resolving meningopolyneuritis (Bann- warth's syndrome) in its progressive nature, its invasion of the nervous system, and in the long lasting injurious effect especially if not treated effectively [13]. Numerous reports have now appeared of patients who several years after they had experienced ECM developed symptoms and evi- dence of chronic inflammation of the central nervous system; it is now well known that B. burgdorferi may cause a wide range of acute, chronic and progressive abnormalities mimicking a variety of other neurologic conditions, such as multiple sclerosis and amyotrophic lateral sclerosis. Apparently, the spirochete is capable of surviving in the central nervous system for years before producing evidence of clinical disease. Intrathecal antibody determinations are the most significant test for Lyme neuroborreliosis. Unfortunately, antibody is not always found in the cerebrospinal fluid, making the diagnosis of this disorder difficult. Subtle development of CNS symptoms, such as memory loss, somnolence, behavioral changes, and depression, following classic Lyme borreliosis, have become a controversial issue especially in the absence of intrathecal antibodies. Many physicians consider such symptoms epiphenomena, i.e. unrelated to Lyme borreliosis, and refuse treatment. On the other hand, a recent study of chronic neurologic manifestations of Lyme disease has shown that the most common form of central nervous system involvement is subacute encephalopathy affecting memory, mood and sleep, and sometimes also speech [14].

Ik denk dat je van encephalomyelitis, psychiatrische aandoeningen kunt krijgen.

[Henriëtte]

Tijdschrift voor psychiatrie 2017, een artikel m.b.t. psychiatrische stoornissen en Lyme

http://www.tijdschriftvoorpsychiatrie.n ... icles/9344

Henriëtte

[Sproetje]

Filmpje Juli 2017
Uit: USA Today

https://www.usatoday.com/story/news/nat ... 493934001/

[Henriëtte]

Tijdschrift voor Psychiatrie / Oktober Bulletin 2017, pdf bestand

http://www.tijdschriftvoorpsychiatrie.n ... 35-243.pdf

Henriëtte

[VerlorengezondheidM]

About 1200 Suicides in the US Each Year Result from Lyme & Associated Diseases

Bron: Robert Bransfield, MD on YouTube, kijk en luister meer