Welkom bij het Lymeforum

Conclusion

In summary, we found that daunomycin and daptomycin were more active against B. burgdorferi biofilm-like structures than mitomycin C and doxorubicin in single drug comparisons as well as in drug combinations. Daunomycin or daptomycin when added to doxycycline + cefuroxime completely eradicated the biofilm-like structures, while the two drug combination doxycycline + cefuroxime alone or mitomycin C and doxorubicin when added to the above combination failed to do so. Additionally, we showed that cefuroxime (Ceftin) could replace cefoperazone in the daptomycin + doxycycline combination and caused complete eradication of the biofilm-like structures. Future studies are needed to evaluate these promising drug combinations in vivo in animal models, and if promising, in patients. Our findings may have implications for improved treatment of Lyme disease.