Ongelooflijk dat er in 15 jaar tijd niks is veranderd.
55% with chronic Lyme are sero-negative
55% with chronic Lyme are sero-negative
Antibiotics: If patients are taking antibiotics at the time of the Lyme disease test, they may not produce enough antibodies to be detected by the test.
Weakened Immune System: False negatives can also result in patients in whom the immune system is weakened or compromised due to coinfection with another illness.
Seronegative patients: These patients do not produce antibodies
Voor het eerst heeft het RIVM Rijksinstituut voor Volksgezondheid en Milieu samen met het Diakonessenhuis Utrecht aangetoond dat het verschil in de uitkomst van serologische testen voor de ziekte van Lyme van het zenuwstelsel sterk geassocieerd is met eerder antibioticagebruik voor de ziekte van Lyme. In een retrospectieve studie (een studie waarbij gebruik gemaakt wordt van reeds aanwezige patiëntgegevens en bloedmonsters) keken onderzoekers naar antistoffen in het bloed. Antistoffen zijn eiwitten die het afweersysteem van het lichaam maakt tegen ‘ongewenste indringers’. Om deze antistoffen te vinden gebruikten zij twee testen: de C6-ELISA Enzyme-Linked Immunosorbent assay en de SERION-ELISA.
Ticks and Lyme disease: The problem 'no one's really doing anything about'
“My body wasn’t fighting it any longer,” she said. “Some doctors say the people who are the sickest don’t produce all the antibodies because the bacteria’s home. It’s having a party. It lives there.”
Rest in Peace, Tammy Hermary who had Lyme disease, she could barely walk. Sorry we failed her.
Abstract
The diagnosis of Lyme disease often depends on the measurement of serum antibodies to Borrelia burgdorferi, the spirochete that causes this disorder. Although prompt treatment with antibiotics may abrogate the antibody response to the infection, symptoms persist in some patients. We studied 17 patients who had presented with acute Lyme disease and received prompt treatment with oral antibiotics, but in whom chronic Lyme disease subsequently developed. Although these patients had clinically active disease, none had diagnostic levels of antibodies to B. burgdorferi on either a standard enzyme-linked immunosorbent assay or immunofluorescence assay. On Western blot analysis, the level of immunoglobulin reactivity against B. burgdorferi in serum from these patients was no greater than that in serum from normal controls. The patients had a vigorous T-cell proliferative response to whole B. burgdorferi, with a mean ( +/- SEM) stimulation index of 17.8 +/- 3.3, similar to that (15.8 +/- 3.2) in 18 patients with chronic Lyme disease who had detectable antibodies. The T-cell response of both groups was greater than that of a control group of healthy subjects (3.1 +/- 0.5; P less than 0.001). We conclude that the presence of chronic Lyme disease cannot be excluded by the absence of antibodies against B. burgdorferi and that a specific T-cell blastogenic response to B. burgdorferi is evidence of infection in seronegative patients with clinical indications of chronic Lyme disease.
The Long-Term Course of Lyme Arthritis in Children
(NEJM 1991 Allen Steere)
https://www.nejm.org/doi/10.1056/NEJM199107183250304
Excerpt:
-After the third year of infection IgG antibody response declined, but remained positive throughout the illness
Carl Tuttle’s comment:
“IgG antibody response declined”….So this would correlate well with patient experience of having a negative Lyme test (that did not meet CDC positive criteria) the longer the infection goes before diagnosis.
Additional supporting interview with Dr. Alfred Miller regarding negative test results:
NIGHTSIDE – A NEW PERSPECTIVE ON LYME DISEASE (2017)
https://madisonarealymesupportgroup.com ... e-disease/
BOSTON (CBS) – Dr. Alfred Miller is a Mayo Clinic trained physician with four decades of experience running a private practice.
Excerpt:
A Couple of points: “Some patients NEVER test positive on any Lyme test and/or coinfection test for that matter. In fact a highly reputable LLMD in WI states the very sickest patients often never test positive.”
OPA (87) LOOPT MARATHON VOOR KLEINDOCHTER MET LYME
De reguliere ELISA lymetest was negatief. Denise eindigde uiteindelijk met het stempel ‘chronisch vermoeidheidsyndroom’ en moest volgens de artsen revalideren. Toen de familie er echter achter kwam dat de ELISA lymetest als onbetrouwbaar bekendstond, deden ze uitgebreidere testen in zowel Nederland als in het buitenland. Daar kwam een hele andere conclusie uit: de ziekte van Lyme met een heleboel co-infecties.
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